Ontology highlight
ABSTRACT:
SUBMITTER: Hartwell KA
PROVIDER: S-EPMC4009363 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Hartwell Kimberly A KA Miller Peter G PG Mukherjee Siddhartha S Kahn Alissa R AR Stewart Alison L AL Logan David J DJ Negri Joseph M JM Duvet Mildred M Järås Marcus M Puram Rishi R Dancik Vlado V Al-Shahrour Fatima F Kindler Thomas T Tothova Zuzana Z Chattopadhyay Shrikanta S Hasaka Thomas T Narayan Rajiv R Dai Mingji M Huang Christina C Shterental Sebastian S Chu Lisa P LP Haydu J Erika JE Shieh Jae Hung JH Steensma David P DP Munoz Benito B Bittker Joshua A JA Shamji Alykhan F AF Clemons Paul A PA Tolliday Nicola J NJ Carpenter Anne E AE Gilliland D Gary DG Stern Andrew M AM Moore Malcolm A S MAS Scadden David T DT Schreiber Stuart L SL Ebert Benjamin L BL Golub Todd R TR
Nature chemical biology 20131027 12
Efforts to develop more effective therapies for acute leukemia may benefit from high-throughput screening systems that reflect the complex physiology of the disease, including leukemia stem cells (LSCs) and supportive interactions with the bone marrow microenvironment. The therapeutic targeting of LSCs is challenging because LSCs are highly similar to normal hematopoietic stem and progenitor cells (HSPCs) and are protected by stromal cells in vivo. We screened 14,718 compounds in a leukemia-stro ...[more]