Functional polymorphisms in toll-like receptor 4 are associated with worse outcome in acute ischemic stroke patients.
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ABSTRACT:
SUBMITTER: Weinstein JR
PROVIDER: S-EPMC4009512 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
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Functional polymorphisms in toll-like receptor 4 are associated with worse outcome in acute ischemic stroke patients.
Weinstein Jonathan R JR Schulze Juliane J Lee Richard V RV Phillips Hunter H Zierath Dannielle D Tanzi Patricia P Shibata Dean D Cain Kevin C KC Becker Kyra J KJ
Neuroreport 20140501 8
Toll-like receptor-4 (TLR4) is important in neuroinflammation. Single nucleotide polymorphisms (SNPs) in TLR4, including 1063 A/G [Asp299Gly] and 1363 C/T [Thr399Ile], are associated with altered immune responses but their effect on acute ischemic stroke (AIS) outcome is unknown. We collected demographic, clinical, laboratory, radiologic, and genotype data on 113 AIS patients and performed multivariate analyses to assess associations between TLR4 SNP haplotype and either neurological outcome, in ...[more]
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