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Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.

ABSTRACT: Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network constellation in mental disease, drug discovery, and interventional therapies.

SUBMITTER: Buzsaki G

PROVIDER: S-EPMC4009705 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Scaling brain size, keeping timing: evolutionary preservation of brain rhythms.

Buzsáki György G Logothetis Nikos N Singer Wolf W

Neuron 20131001 3

Despite the several-thousand-fold increase of brain volume during the course of mammalian evolution, the hierarchy of brain oscillations remains remarkably preserved, allowing for multiple-time-scale communication within and across neuronal networks at approximately the same speed, irrespective of brain size. Deployment of large-diameter axons of long-range neurons could be a key factor in the preserved time management in growing brains. We discuss the consequences of such preserved network cons ...[more]

PMID: 24183025

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