Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
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ABSTRACT:
SUBMITTER: Tkach AV
PROVIDER: S-EPMC4009732 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells.
Tkach Alexey V AV Yanamala Naveena N Stanley Shyla S Shurin Michael R MR Shurin Galina V GV Kisin Elena R ER Murray Ashley R AR Pareso Samantha S Khaliullin Timur T Kotchey Gregg P GP Castranova Vincent V Mathur Sanjay S Fadeel Bengt B Star Alexander A Kagan Valerian E VE Shvedova Anna A AA
Small (Weinheim an der Bergstrasse, Germany) 20120813 9-10
Graphene oxide (GO) and C60 - or C60 -TRIS fullerenes, internalized by murine dendritic cells (DCs), differently affect their abilities to present antigens to T-cells. While C60 -fullerenes stimulate the ovalbumin-specific MHC class I-restricted T-cell response, GO impairs the stimulatory potential of DCs. In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC ...[more]
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