Ontology highlight
ABSTRACT:
SUBMITTER: Wright DW
PROVIDER: S-EPMC4009785 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Biology 20120726 2
HIV-1 Reverse Transcriptase (RT) is a multifunctional enzyme responsible for the transcription of the RNA genome of the HIV virus into DNA suitable for incorporation within the DNA of human host cells. Its crucial role in the viral life cycle has made it one of the major targets for antiretroviral drug therapy. The Non-Nucleoside RT Inhibitor (NNRTI) class of drugs binds allosterically to the enzyme, affecting many aspects of its activity. We use both coarse grained network models and atomistic ...[more]