Ontology highlight
ABSTRACT:
SUBMITTER: Cummins NW
PROVIDER: S-EPMC4010171 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Cummins Nathan W NW Neuhaus Jacqueline J Sainski Amy M AM Strausbauch Michael A MA Wettstein Peter J PJ Lewin Sharon R SR Plana Montserrat M Rizza Stacey A SA Temesgen Zelalem Z Touloumi Giota G Freiberg Matthew M Neaton James J Badley Andrew D AD
AIDS research and human retroviruses 20140214 5
Most patients on suppressive antiretroviral therapy (ART) experience improvements in CD4 T cell count. However, some patients with undetectable viral load continue to lose CD4 T cells for unknown reasons. Casp8p41 is a host-derived protein fragment that is present only in productively infected cells and that causes the death of HIV-infected cells. We questioned whether ongoing CD4(+) T cell losses while on suppressive ART were associated with subclinical HIV replication causing production of Cas ...[more]