Ontology highlight
ABSTRACT:
SUBMITTER: Bowden SD
PROVIDER: S-EPMC4010460 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bowden Steven D SD Hopper-Chidlaw Amanda C AC Rice Christopher J CJ Ramachandran Vinoy K VK Kelly David J DJ Thompson Arthur A
PloS one 20140505 5
Salmonella is the causative agent of a spectrum of human and animal diseases ranging from gastroenteritis to typhoid fever. It is a food--and water--borne pathogen and infects via ingestion followed by invasion of intestinal epithelial cells and phagocytic cells. In this study we employed a mutational approach to define the nutrients and metabolic pathways required by Salmonella enterica serovar Typhimurium during infection of a human epithelial cell line (HeLa). We deleted the key glycolytic ge ...[more]