Ontology highlight
ABSTRACT:
SUBMITTER: Murray EJ
PROVIDER: S-EPMC4010551 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Murray Ewan J EJ Crowley Rebecca C RC Truman Alex A Clarke Simon R SR Cottam James A JA Jadhav Gopal P GP Steele Victoria R VR O'Shea Paul P Lindholm Catharina C Cockayne Alan A Chhabra Siri Ram SR Chan Weng C WC Williams Paul P
Journal of medicinal chemistry 20140313 6
A series of 3-oxo-C12-HSL, tetramic acid, and tetronic acid analogues were synthesized to gain insights into the structural requirements for quorum sensing inhibition in Staphylococcus aureus. Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (AIP) activated AgrC receptor, by altering the activation efficacy of the cognate AIP-1. They appeared to act as negative allosteric modulators and are exemplified by 3-tetradecanoyltetronic acid 17, which reduced nasal ...[more]