Ontology highlight
ABSTRACT:
SUBMITTER: Meng F
PROVIDER: S-EPMC4010652 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Meng Fanyin F DeMorrow Sharon S Venter Julie J Frampton Gabriel G Han Yuyan Y Francis Heather H Standeford Holly H Avila Shanika S McDaniel Kelly K McMillin Matthew M Afroze Syeda S Guerrier Micheleine M Quezada Morgan M Ray Debolina D Kennedy Lindsey L Hargrove Laura L Glaser Shannon S Alpini Gianfranco G
American journal of physiology. Gastrointestinal and liver physiology 20140306 9
Substance P (SP) promotes cholangiocyte growth during cholestasis by activating its receptor, NK1R. SP is a proteolytic product of tachykinin (Tac1) and is deactivated by membrane metalloendopeptidase (MME). This study aimed to evaluate the functional role of SP in the regulation of cholangiocarcinoma (CCA) growth. NK1R, Tac1, and MME expression and SP secretion were assessed in human CCA cells and nonmalignant cholangiocytes. The proliferative effects of SP (in the absence/presence of the NK1R ...[more]