The specificity of DNA recognition by the RAGE receptor.
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ABSTRACT:
SUBMITTER: Yatime L
PROVIDER: S-EPMC4010895 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
The specificity of DNA recognition by the RAGE receptor.
Yatime Laure L Andersen Gregers Rom GR
The Journal of experimental medicine 20140428 5
A recent paper by Sirois et al. in The Journal of Experimental Medicine reports that the receptor for advanced glycation end-products (RAGE) promotes uptake of DNA into endosomes and lowers the immune recognition threshold for the activation of Toll-like receptor 9. Two crystal structures suggested that the DNA phosphate-deoxyribose backbone is recognized by RAGE through well-defined interactions. However, the electron densities for the DNA molecules are weak enough that the presented modeling o ...[more]
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