Ontology highlight
ABSTRACT:
SUBMITTER: St Pierre CA
PROVIDER: S-EPMC4011639 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
St Pierre Christine A CA Chan Melvin M Iwakura Yoichiro Y Ayers David C DC Kurt-Jones Evelyn A EA Finberg Robert W RW
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20101101 11
Osteolysis of bone following total hip replacement is a major clinical problem. Examination of the areas surrounding failed implants has indicated an increase in the bone-resorption-inducing cytokine, interleukin 1β (IL-1β). NALP3, a NOD-like receptor protein located in the cytosol of macrophages, signals the cleavage of pro-IL-1β into its mature, secreted form, IL-1β. Here we showed that titanium particles stimulate the NALP3 inflammasome. We demonstrated that titanium induces IL-1β secretion f ...[more]