Ontology highlight
ABSTRACT:
SUBMITTER: Sanfelice D
PROVIDER: S-EPMC4011691 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sanfelice Domenico D Puglisi Rita R Martin Stephen R SR Di Bari Lorenzo L Pastore Annalisa A Temussi Piero Andrea PA
PloS one 20140506 5
Frataxins are a family of metal binding proteins associated with the human Friedreich's ataxia disease. Here, we have addressed the effect of non-specifically binding salts on the stability of the yeast ortholog Yfh1. This protein is a sensitive model since its stability is strongly dependent on the environment, in particular on ionic strength. Yfh1 also offers the unique advantage that its cold denaturation can be observed above the freezing point of water, thus allowing the facile construction ...[more]