Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.
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ABSTRACT:
SUBMITTER: Shaw S
PROVIDER: S-EPMC4011921 | biostudies-literature | 2014 May-Jun
REPOSITORIES: biostudies-literature
Publications
Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling.
Shaw Stevan S Bourne Tim T Bourne Tim T Meier Chris C Carrington Bruce B Gelinas Rich R Henry Alistair A Popplewell Andrew A Adams Ralph R Baker Terry T Rapecki Steve S Marshall Diane D Moore Adrian A Neale Helen H Lawson Alastair A
mAbs 20140402 3
Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at "Site 3", blocking the interaction with the signaling co-receptor gp130. ...[more]
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