Ontology highlight
ABSTRACT:
SUBMITTER: Cartwright EK
PROVIDER: S-EPMC4011949 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Cartwright Emily K EK McGary Colleen S CS Cervasi Barbara B Micci Luca L Lawson Benton B Elliott Sarah T C ST Collman Ronald G RG Bosinger Steven E SE Paiardini Mirko M Vanderford Thomas H TH Chahroudi Ann A Silvestri Guido G
Journal of immunology (Baltimore, Md. : 1950) 20140411 10
Recent studies have identified a subset of memory T cells with stem cell-like properties (T(SCM)) that include increased longevity and proliferative potential. In this study, we examined the dynamics of CD4(+) T(SCM) during pathogenic SIV infection of rhesus macaques (RM) and nonpathogenic SIV infection of sooty mangabeys (SM). Whereas SIV-infected RM show selective numeric preservation of CD4(+) T(SCM), SIV infection induced a complex perturbation of these cells defined by depletion of CD4(+)CC ...[more]