Ontology highlight
ABSTRACT:
SUBMITTER: Hutcheson RU
PROVIDER: S-EPMC4012327 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Hutcheson Rachel U RU Broderick Joan B JB
Metallomics : integrated biometal science 20120919 11
Radical S-adenosyl-l-methionine (SAM) enzymes are a large and diverse superfamily with functions ranging from enzyme activation through a single H atom abstraction to complex organic and metal cofactor synthesis involving a series of steps. Though these enzymes carry out a variety of functions, they share common structural and mechanistic characteristics. All of them contain a site-differentiated [4Fe-4S] cluster, ligated by a CX(3)CX(2)C or similar motif, which binds SAM at the unique iron. The ...[more]