Ontology highlight
ABSTRACT:
SUBMITTER: Inagaki A
PROVIDER: S-EPMC4012382 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Inagaki Akira A Frank C Andrew CA Usachev Yuriy M YM Benveniste Morris M Lee Amy A
Neuron 20140101 1
Voltage-gated ion channels exhibit complex properties, which can be targeted in pharmacological therapies for disease. Here, we report that the pro-oxidant, tert-butyl dihydroquinone (BHQ), modulates Ca(v)2.1 Ca²⁺ channels in ways that oppose defects in channel gating and synaptic transmission resulting from a familial hemiplegic migraine mutation (S218L). BHQ slows deactivation, inhibits voltage-dependent activation, and potentiates Ca²⁺-dependent facilitation of Ca(v)2.1 channels in transfecte ...[more]