Ontology highlight
ABSTRACT:
SUBMITTER: Guffanti G
PROVIDER: S-EPMC4012421 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Genomics 20130411 2
We investigated the genome-wide distribution of CNVs in the Alzheimer's disease (AD) Neuroimaging Initiative (ADNI) sample (146 with AD, 313 with Mild Cognitive Impairment (MCI), and 181 controls). Comparison of single CNVs between cases (MCI and AD) and controls shows overrepresentation of large heterozygous deletions in cases (p-value<0.0001). The analysis of CNV-Regions identifies 44 copy number variable loci of heterozygous deletions, with more CNV-Regions among affected than controls (p=0.0 ...[more]