Efficient imputation of missing markers in low-coverage genotyping-by-sequencing data from multiparental crosses.
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ABSTRACT:
SUBMITTER: Huang BE
PROVIDER: S-EPMC4012496 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Efficient imputation of missing markers in low-coverage genotyping-by-sequencing data from multiparental crosses.
Huang B Emma BE Raghavan Chitra C Mauleon Ramil R Broman Karl W KW Leung Hei H
Genetics 20140228 1
We consider genomic imputation for low-coverage genotyping-by-sequencing data with high levels of missing data. We compensate for this loss of information by utilizing family relationships in multiparental experimental crosses. This nearly quadruples the number of usable markers when applied to a large rice Multiparent Advanced Generation InterCross (MAGIC) study. ...[more]
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