Ontology highlight
ABSTRACT:
SUBMITTER: Huang SW
PROVIDER: S-EPMC4012728 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Huang Shi-Wei SW Kao Jun-Kai JK Wu Chun-Ying CY Wang Sin-Ting ST Lee Hsin-Chen HC Liang Shu-Mei SM Chen Yi-Ju YJ Shieh Jeng-Jer JJ
Oncotarget 20140301 5
Tumor cells rely on aerobic glycolysis to maintain unconstrained cell growth and proliferation. Imiquimod (IMQ), a synthetic Toll-like receptor (TLR) 7/8 ligand, exerts anti-tumor effects directly by inducing cell death in cancer cells and/or indirectly by activating cellular immune responses against tumor cells. However, whether IMQ modulates glucose metabolism pathways remains unclear. In this study, we demonstrated that IMQ can enhance aerobic glycolysis by up-regulating HIF-1α expression at ...[more]