Androgen receptor gene and sex-specific Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Ferrari R
PROVIDER: S-EPMC4012749 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Androgen receptor gene and sex-specific Alzheimer's disease.
Ferrari Raffaele R Dawoodi Saad S Raju Merrill M Thumma Avinash A Hynan Linda S LS Maasumi Shirin Hejazi SH Reisch Joan S JS O'Bryant Sid S Jenkins Marjorie M Barber Robert R Momeni Parastoo P
Neurobiology of aging 20130329 8
Women are at a 2-fold risk of developing late-onset Alzheimer's disease (AD) (onset at 65 years of age or older) compared with men. During perimenopausal years, women undergo hormonal changes that are accompanied by metabolic, cardiovascular, and inflammatory changes. These all together have been suggested as risk factors for late-onset AD. However, not all perimenopausal women develop AD; we hypothesize that certain genetic factors might underlie the increased susceptibility for developing AD i ...[more]
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