Ontology highlight
ABSTRACT:
SUBMITTER: Murakami-Tonami Y
PROVIDER: S-EPMC4013162 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Murakami-Tonami Yuko Y Kishida Satoshi S Takeuchi Ichiro I Katou Yuki Y Maris John M JM Ichikawa Hitoshi H Kondo Yutaka Y Sekido Yoshitaka Y Shirahige Katsuhiko K Murakami Hiroshi H Kadomatsu Kenji K
Cell cycle (Georgetown, Tex.) 20140207 7
The condensin complex is required for chromosome condensation during mitosis; however, the role of this complex during interphase is unclear. Neuroblastoma is the most common extracranial solid tumor of childhood, and it is often lethal. In human neuroblastoma, MYCN gene amplification is correlated with poor prognosis. This study demonstrates that the gene encoding the condensin complex subunit SMC2 is transcriptionally regulated by MYCN. SMC2 also transcriptionally regulates DNA damage response ...[more]