Ontology highlight
ABSTRACT:
SUBMITTER: Li LL
PROVIDER: S-EPMC4013349 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Chinese journal of cancer 20110401 4
Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia. Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications. These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC. In this review, we summarize the epigenetic deregulati ...[more]