Ontology highlight
ABSTRACT:
SUBMITTER: Lenglet S
PROVIDER: S-EPMC4013777 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Lenglet Sébastien S Montecucco Fabrizio F Denes Adam A Coutts Graham G Pinteaux Emmanuel E Mach François F Schaller Karl K Gasche Yvan Y Copin Jean-Christophe JC
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140129 5
The effect of recombinant human tissue plasminogen activator (rtPA) on neuroinflammation after stroke remains largely unknown. Here, we tested the effect of rtPA on expression of cellular adhesion molecules, chemokines, and cytokines, and compared those with levels of inflammatory cell recruitment, brain injury, and mortality over 3 days after transient middle cerebral artery occlusion (MCAO) in mice. Mortality was dramatically increased after rtPA treatment compared with saline treatment during ...[more]