Ontology highlight
ABSTRACT:
SUBMITTER: Dupre A
PROVIDER: S-EPMC4014304 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Dupré Aude A Daldello Enrico M EM Nairn Angus C AC Jessus Catherine C Haccard Olivier O
Nature communications 20140101
During oogenesis, oocytes are arrested in prophase and resume meiosis by activating the kinase Cdk1 upon hormonal stimulation. In all vertebrates, release from prophase arrest relies on protein kinase A (PKA) downregulation and on the dephosphorylation of a long sought but still unidentified substrate. Here we show that ARPP19 is the PKA substrate whose phosphorylation at serine 109 is necessary and sufficient for maintaining Xenopus oocytes arrested in prophase. By downregulating PKA, progester ...[more]