Ontology highlight
ABSTRACT:
SUBMITTER: Kedzierski L
PROVIDER: S-EPMC4014316 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
PLoS pathogens 20140508 5
Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pathogenic H1N1 influenza virus (PR8) and are hypersusceptible to infection with the less virulent H3N2 (X31) strain. In SOCS4-deficient animals, this led to substantially greater weight loss, dysregula ...[more]