Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC4015113 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Zhao X X Lwin T T Zhang X X Huang A A Wang J J Marquez V E VE Chen-Kiang S S Dalton W S WS Sotomayor E E Tao J J
Leukemia 20130329 12
c-MYC (hereafter MYC) overexpression has been recognized in aggressive B-cell lymphomas and linked to adverse prognosis. MYC activation results in widespread repression of micro-RNA (miRNA) expression and associated with lymphoma aggressive progression. Our recent study identified a MYC-miRNA-EZH2 feed-forward loop linking overexpression of MYC, EZH2 and miRNA repression. Here, using a novel small-molecule BET bromodomain inhibitor, JQ1, and the EZH2 inhibitor, DZNep, we demonstrated that combin ...[more]