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Interfacial polygonal patterning via surfactant-mediated self-assembly of gold nanoparticles.

ABSTRACT: In this work, we explored the formation processes of interfacial polygonal patterning via surfactant-mediated self-assembly of gold nanoparticles (AuNPs). We found that a balance between DDT-capped AuNPs and PVP-passivated AuNPs is a key to making these inorganic-organic thin films. The interfacial polygonal patterning possesses many processing advantages and flexibilities, such as controllable interfacial shape and inter-AuNP distance, tuning of particle sizes, thiol population, chain lengths, and other new properties by introducing functional groups to thiol chains. In principle, self-assembly of AuNPs via well-designed interfaces may be useful for fabrications of other complex architectures.

SUBMITTER: Zhang YX

PROVIDER: S-EPMC4015365 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Interfacial polygonal patterning via surfactant-mediated self-assembly of gold nanoparticles.

Zhang Yu Xin YX Hao Xiao Dong XD Kuang Min M De Chen Ru R

Nanoscale research letters 20131022 1

In this work, we explored the formation processes of interfacial polygonal patterning via surfactant-mediated self-assembly of gold nanoparticles (AuNPs). We found that a balance between DDT-capped AuNPs and PVP-passivated AuNPs is a key to making these inorganic-organic thin films. The interfacial polygonal patterning possesses many processing advantages and flexibilities, such as controllable interfacial shape and inter-AuNP distance, tuning of particle sizes, thiol population, chain lengths, ...[more]

PMID: 24144325

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Project description:BackgroundProtocell refers to the basic unit of life and synthetic molecular assembly with cell structure and function. The protocells have great applications in the field of biomedical technology. Simulating the morphology and function of cells is the key to the preparation of protocells. However, some organic solvents used in the preparation process of protocells would damage the function of the bioactive substance. Perfluorocarbon, which has no toxic effect on bioactive substances, is an ideal solvent for protocell preparation. However, perfluorocarbon cannot be emulsified with water because of its inertia.MethodsSpheroids can be formed in nature even without emulsification, since liquid can reshape the morphology of the solid phase through the scouring action, even if there is no stable interface between the two phases. Inspired by the formation of natural spheroids such as pebbles, we developed non-interfacial self-assembly (NISA) of microdroplets as a step toward synthetic protocells, in which the inert perfluorocarbon was utilized to reshape the hydrogel through the scouring action.ResultsThe synthetic protocells were successfully obtained by using NISA-based protocell techniques, with the morphology very similar to native cells. Then we simulated the cell transcription process in the synthetic protocell and used the protocell as an mRNA carrier to transfect 293T cells. The results showed that protocells delivered mRNAs, and successfully expressed proteins in 293T cells. Further, we used the NISA method to fabricate an artificial cell by extracting and reassembling the membrane, proteins, and genomes of ovarian cancer cells. The results showed that the recombination of tumor cells was successfully achieved with similar morphology as tumor cells. In addition, the synthetic protocell prepared by the NISA method was used to reverse cancer chemoresistance by restoring cellular calcium homeostasis, which verified the application value of the synthetic protocell as a drug carrier.ConclusionThis synthetic protocell fabricated by the NISA method simulates the occurrence and development process of primitive life, which has great potential application value in mRNA vaccine, cancer immunotherapy, and drug delivery.

Dataset Information

Interfacial polygonal patterning via surfactant-mediated self-assembly of gold nanoparticles.

Publications

Interfacial polygonal patterning via surfactant-mediated self-assembly of gold nanoparticles.

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