Ontology highlight
ABSTRACT:
SUBMITTER: Parekh G
PROVIDER: S-EPMC4015802 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Parekh Gaurav G Pattekari Pravin P Joshi Chaitanya C Shutava Tatsiana T DeCoster Mark M Levchenko Tatyana T Torchilin Vladimir V Lvov Yuri Y
International journal of pharmaceutics 20140206 1-2
160 nm nanocapsules containing up to 60% of camptothecin in the core and 7-8 polyelectrolyte bilayers in the shell were produced by washless layer-by-layer assembly of heparin and block-copolymer of poly-l-lysine and polyethylene glycol. The outer surface of the nanocapsules was additionally modified with polyethylene glycol of 5 kDa or 20 kDa molecular weight to attain protein resistant properties, colloidal stability in serum and prolonged release of the drug from the capsules. An advantage of ...[more]