Ontology highlight
ABSTRACT:
SUBMITTER: Hung N
PROVIDER: S-EPMC4015841 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Hung Noelyn N Chen Yu-Jen YJ Taha Ahmad A Olivecrona Magnus M Boet Ronald R Wiles Anna A Warr Tracy T Shaw Alisha A Eiholzer Ramona R Baguley Bruce C BC Eccles Michael R MR Braithwaite Antony W AW Macfarlane Martin M Royds Janice A JA Slatter Tania T
BMC cancer 20140306
<h4>Background</h4>The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by the paired box transcription factor 8 (PAX8). In earlier studies, we demonstrated that increased PAX8 expression in glioma cell lines was associated with the expression of telomerase. In this current study, we more extensively explored a role for PAX8 in gliomagenesis.<h4 ...[more]