Ontology highlight
ABSTRACT:
SUBMITTER: Schiller C
PROVIDER: S-EPMC4015914 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Schiller Christian C Nowak Carina C Diakopoulos Kalliope N KN Weidle Ulrich H UH Weiss Elisabeth H EH
PloS one 20140509 5
The regulation of gene expression depends on the interplay of multiple factors at the transcriptional and translational level. Upstream open reading frames (uORFs) play an important role as translational repressors of main ORFs and their presence or usage in transcripts can be regulated by different mechanisms. The main objective of the present study was to assess whether uORFs regulate the expression of the MHC class III gene LST1. We report that expression of LST1 is tightly regulated by alter ...[more]