Ontology highlight
ABSTRACT:
SUBMITTER: Moon J
PROVIDER: S-EPMC4016011 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Moon Jiyoung J Park Sang-Hyun SH
PloS one 20140509 5
Formation of signaling protein complexes is crucial for proper signal transduction. Scaffold proteins in MAP kinase pathways are thought to facilitate complex assembly, thereby promoting efficient and specific signaling. To elucidate the assembly mechanism of scaffold complexes in mammals, we attempted to rationally rewire JIP1-dependent JNK MAP kinase pathway via alternative assembly of JIP1 complex. When JIP1-JNK docking interaction in the complex was replaced with heterologous protein interac ...[more]