Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez W
PROVIDER: S-EPMC4016191 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Hernandez W W Gamazon E R ER Aquino-Michaels K K Patel S S O'Brien T J TJ Harralson A F AF Kittles R A RA Barbour A A Tuck M M McIntosh S D SD Douglas J N JN Nicolae D D Cavallari L H LH Perera M A MA
The pharmacogenomics journal 20130910 3
Using a derivation cohort (N=349), we developed the first warfarin dosing algorithm that includes recently discovered polymorphisms in VKORC1 and CYP2C9 associated with warfarin dose requirement in African Americans (AAs). We tested our novel algorithm in an independent cohort of 129 AAs and compared the dose prediction to the International Warfarin Pharmacogenetics Consortium (IWPC) dosing algorithms. Our algorithm explains more of the phenotypic variation (R(2)=0.27) than the IWPC pharmacogeno ...[more]