Comparison of metabolic ratios of urinary estrogens between benign and malignant thyroid tumors in postmenopausal women.
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ABSTRACT: Background
Estrogen metabolism may be associated with the pathophysiological development of papillary thyroid carcinoma (PTC).Methods
To evaluate the differential estrogen metabolism between benign and malignant PTCs, estrogen profiling by gas chromatography-mass spectrometry was applied to urine samples from postmenopausal patients with 9 benign tumors and 18 malignant stage I and III/IV PTCs.Results
The urinary concentration of 2-methoxyestradiol was significantly lower in the stage I malignant patients (3.5-fold; P?3.5-fold difference; P?ConclusionsIncreased 16?-hydroxylation and/or a decreased 2-/16?-ratio, as well increased reductive 17?-HSD, with regard to estrogen metabolism could provide potential biomarkers. The devised profiles could be useful for differentiating malignant thyroid carcinomas from benign adenomas in postmenopausal women.
SUBMITTER: Moon JY
PROVIDER: S-EPMC4016477 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Comparison of metabolic ratios of urinary estrogens between benign and malignant thyroid tumors in postmenopausal women.
Moon Ju-Yeon JY Lee Eun Jig EJ Chung Woong Youn WY Moon Myeong Hee MH Chung Bong Chul BC Choi Man Ho MH
BMC clinical pathology 20131025 1
<h4>Background</h4>Estrogen metabolism may be associated with the pathophysiological development of papillary thyroid carcinoma (PTC).<h4>Methods</h4>To evaluate the differential estrogen metabolism between benign and malignant PTCs, estrogen profiling by gas chromatography-mass spectrometry was applied to urine samples from postmenopausal patients with 9 benign tumors and 18 malignant stage I and III/IV PTCs.<h4>Results</h4>The urinary concentration of 2-methoxyestradiol was significantly lower ...[more]
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