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Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.


ABSTRACT: Research to date demonstrates a relationship between exposure to ambient air pollutants and cardiovascular disease (CVD). Many studies have shown associations between short-term exposures to elevated levels of air pollutants and CVD events, and several cohort studies suggest effects of long-term exposure on cardiovascular mortality, coronary heart disease events, and stroke. The biologic mechanisms underlying this long-term exposure relationship are not entirely clear but are hypothesized to include systemic inflammation, autonomic nervous system imbalance, changes in vascular compliance, altered cardiac structure, and development of atherosclerosis. The Multi-Ethnic Study of Atherosclerosis provides an especially well-characterized population in which to investigate the relationship between air pollution and CVD and to explore these biologic pathways. This article reviews findings reported to date within this cohort and summarizes the aims and anticipated contributions of a major ancillary study, the Multi-Ethnic Study of Atherosclerosis and Air Pollution.

SUBMITTER: Gill EA 

PROVIDER: S-EPMC4016948 | biostudies-literature | 2011 Mar-Apr

REPOSITORIES: biostudies-literature

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Air pollution and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.

Gill Edward A EA   Curl Cynthia L CL   Adar Sara D SD   Allen Ryan W RW   Auchincloss Amy H AH   O'Neill Marie S MS   Park Sung Kyun SK   Van Hee Victor C VC   Diez Roux Ana V AV   Kaufman Joel D JD  

Progress in cardiovascular diseases 20110301 5


Research to date demonstrates a relationship between exposure to ambient air pollutants and cardiovascular disease (CVD). Many studies have shown associations between short-term exposures to elevated levels of air pollutants and CVD events, and several cohort studies suggest effects of long-term exposure on cardiovascular mortality, coronary heart disease events, and stroke. The biologic mechanisms underlying this long-term exposure relationship are not entirely clear but are hypothesized to inc  ...[more]

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