Ontology highlight
ABSTRACT:
SUBMITTER: Mar BG
PROVIDER: S-EPMC4016990 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Mar Brenton G BG Bullinger Lars B LB McLean Kathleen M KM Grauman Peter V PV Harris Marian H MH Stevenson Kristen K Neuberg Donna S DS Sinha Amit U AU Sallan Stephen E SE Silverman Lewis B LB Kung Andrew L AL Lo Nigro Luca L Ebert Benjamin L BL Armstrong Scott A SA
Nature communications 20140324
Relapsed paediatric acute lymphoblastic leukaemia (ALL) has high rates of treatment failure. Epigenetic regulators have been proposed as modulators of chemoresistance, here, we sequence genes encoding epigenetic regulators in matched diagnosis-remission-relapse ALL samples. We find significant enrichment of mutations in epigenetic regulators at relapse with recurrent somatic mutations in SETD2, CREBBP, MSH6, KDM6A and MLL2, mutations in signalling factors are not enriched. Somatic alterations in ...[more]