Ontology highlight
ABSTRACT:
SUBMITTER: Savage KI
PROVIDER: S-EPMC4017265 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Savage Kienan I KI Gorski Julia J JJ Barros Eliana M EM Irwin Gareth W GW Manti Lorenzo L Powell Alexander J AJ Pellagatti Andrea A Lukashchuk Natalia N McCance Dennis J DJ McCluggage W Glenn WG Schettino Giuseppe G Salto-Tellez Manuel M Boultwood Jacqueline J Richard Derek J DJ McDade Simon S SS Harkin D Paul DP
Molecular cell 20140417 3
Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through the assembly of multiple protein complexes involved in DNA repair, cell-cycle arrest, and transcriptional regulation. Here, we report the identification of a DNA damage-induced BRCA1 protein complex containing BCLAF1 and other key components of the mRNA-splicing machinery. In response to DNA damage, this complex regulates pre-mRNA splicing of a number of ...[more]