Ontology highlight
ABSTRACT:
SUBMITTER: Zhou C
PROVIDER: S-EPMC4017609 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140422 18
Although DNA binding proteins shield the genetic material from diffusible reactive oxygen species by reacting with them, the resulting protein (peroxyl) radicals can oxidize the bound DNA. To explore this possible DNA damage by protein radicals, histone H4 proteins containing an azoalkane radical precursor at defined sites were prepared. Photolysis of a nucleosome core particle containing the modified protein produces DNA damage that is consistent with selective C4'-oxidation. The nucleotide(s) ...[more]