Rapid diaphragm atrophy following cervical spinal cord hemisection.
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ABSTRACT:
SUBMITTER: Gill LC
PROVIDER: S-EPMC4017782 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Rapid diaphragm atrophy following cervical spinal cord hemisection.
Gill L C LC Ross H H HH Lee K Z KZ Gonzalez-Rothi E J EJ Dougherty B J BJ Judge A R AR Fuller D D DD
Respiratory physiology & neurobiology 20131214
A cervical (C2) hemilesion (C2Hx), which disrupts ipsilateral bulbospinal inputs to the phrenic nucleus, was used to study diaphragm plasticity after acute spinal cord injury. We hypothesized that C2Hx would result in rapid atrophy of the ipsilateral hemidiaphragm and increases in mRNA expression of proteolytic biomarkers. Diaphragm tissue was harvested from male Sprague-Dawley rats at 1 or 7 days following C2Hx. Histological analysis demonstrated reduction in cross-sectional area (CSA) of type ...[more]
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