Ontology highlight
ABSTRACT:
SUBMITTER: Bettegowda C
PROVIDER: S-EPMC4017867 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Bettegowda Chetan C Sausen Mark M Leary Rebecca J RJ Kinde Isaac I Wang Yuxuan Y Agrawal Nishant N Bartlett Bjarne R BR Wang Hao H Luber Brandon B Alani Rhoda M RM Antonarakis Emmanuel S ES Azad Nilofer S NS Bardelli Alberto A Brem Henry H Cameron John L JL Lee Clarence C CC Fecher Leslie A LA Gallia Gary L GL Gibbs Peter P Le Dung D Giuntoli Robert L RL Goggins Michael M Hogarty Michael D MD Holdhoff Matthias M Hong Seung-Mo SM Jiao Yuchen Y Juhl Hartmut H HH Kim Jenny J JJ Siravegna Giulia G Laheru Daniel A DA Lauricella Calogero C Lim Michael M Lipson Evan J EJ Marie Suely Kazue Nagahashi SK Netto George J GJ Oliner Kelly S KS Olivi Alessandro A Olsson Louise L Riggins Gregory J GJ Sartore-Bianchi Andrea A Schmidt Kerstin K Shih le-Ming lM Oba-Shinjo Sueli Mieko SM Siena Salvatore S Theodorescu Dan D Tie Jeanne J Harkins Timothy T TT Veronese Silvio S Wang Tian-Li TL Weingart Jon D JD Wolfgang Christopher L CL Wood Laura D LD Xing Dongmei D Hruban Ralph H RH Wu Jian J Allen Peter J PJ Schmidt C Max CM Choti Michael A MA Velculescu Victor E VE Kinzler Kenneth W KW Vogelstein Bert B Papadopoulos Nickolas N Diaz Luis A LA
Science translational medicine 20140201 224
The development of noninvasive methods to detect and monitor tumors continues to be a major challenge in oncology. We used digital polymerase chain reaction-based technologies to evaluate the ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types. We found that ctDNA was detectable in >75% of patients with advanced pancreatic, ovarian, colorectal, bladder, gastroesophageal, breast, melanoma, hepatocellular, and head and neck cancers, but in less than ...[more]