Ontology highlight
ABSTRACT:
SUBMITTER: Hille UE
PROVIDER: S-EPMC4018063 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Hille Ulrike E UE Zimmer Christina C Haupenthal Jörg J Hartmann Rolf W RW
ACS medicinal chemistry letters 20110603 8
CYP11B1 is the key enzyme in cortisol biosynthesis, and its inhibition with selective compounds is a promising strategy for the treatment of diseases associated with elevated cortisol levels, such as Cushing's syndrome or metabolic disease. Expanding on a previous study from our group resulting in the first potent and rather selective inhibitor described so far (1, IC50 = 152 nM), we herein describe further optimizations of the imidazolylmethyl pyridine core. Five compounds among the 42 substanc ...[more]