Ontology highlight
ABSTRACT:
SUBMITTER: Schuttelkopf AW
PROVIDER: S-EPMC4018065 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Schüttelkopf Alexander W AW Andersen Ole A OA Rao Francesco V FV Allwood Matthew M Rush Christina L CL Eggleston Ian M IM van Aalten Daan M F DM
ACS medicinal chemistry letters 20110323 6
Chitinases of the GH18 family play important roles in a variety of pathogenic organisms and have also been shown to be involved in human asthma progression, making these enzymes potential drug targets. While a number of potent GH18 chitinase inhibitors have been described, in general, these compounds suffer from limited synthetic accessibility or unfavorable medicinal-chemical properties, making them poor starting points for the development of chitinase-targeted drugs. Exploiting available struc ...[more]