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ABSTRACT:
SUBMITTER: Shinagawa Y
PROVIDER: S-EPMC4018071 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Shinagawa Yuko Y Inoue Teruhiko T Katsushima Takeo T Kiguchi Toshihiro T Ikenogami Taku T Ogawa Naoki N Fukuda Kenji K Hirata Kazuyuki K Harada Kazuhito K Takagi Masaki M Nakagawa Takashi T Kimura Shuichi S Matsuo Yushi Y Maekawa Mariko M Hayashi Mikio M Soejima Yuki Y Takahashi Mitsuru M Shindo Masanori M Hashimoto Hiromasa H
ACS medicinal chemistry letters 20101229 3
Short-acting oral calcilytics, calcium-sensing receptor (CaSR) antagonists, have been considered as alternatives for parathyroid hormone (PTH), an injectable bone anabolic drug used in the treatment of osteoporosis. Previously, we identified aminopropandiol 1, which transiently stimulated endogenous PTH secretion in rats. However, the inhibition of cytochrome P450 (CYP) 2D6 and the low bioavailability of 1 remain to be solved. Attempts to change the physicochemical properties of the highly lipop ...[more]