Dataset Information
A Strategy for Suppressing Redox Stress within Mitochondria.
Ontology highlight
ABSTRACT:
SUBMITTER: Arce PM
PROVIDER: S-EPMC4018135 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
A Strategy for Suppressing Redox Stress within Mitochondria.
ACS medicinal chemistry letters 20110531 8
An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species in cells under oxidative stress. It is thought to do so via a catalytic cycle in which both forms of oxidative stress are suppressed simultaneously. Consequently, the compound effectively protects cultured CEM leukemia cells and Friedreich's ataxia fibroblasts from oxidat ...[more]