Ontology highlight
ABSTRACT:
SUBMITTER: Zeytuni N
PROVIDER: S-EPMC4018254 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Zeytuni Natalie N Uebe René R Maes Michal M Davidov Geula G Baram Michal M Raschdorf Oliver O Friedler Assaf A Miller Yifat Y Schüler Dirk D Zarivach Raz R
PloS one 20140512 5
Cation diffusion facilitators (CDF) are part of a highly conserved protein family that maintains cellular divalent cation homeostasis in all organisms. CDFs were found to be involved in numerous human health conditions, such as Type-II diabetes and neurodegenerative diseases. In this work, we established the magnetite biomineralizing alphaproteobacterium Magnetospirillum gryphiswaldense as an effective model system to study CDF-related Type-II diabetes. Here, we introduced two ZnT-8 Type-II diab ...[more]