Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC4018447 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
Wang Wei W Scheffler Katja K Esbensen Ying Y Strand Janne M JM Stewart James B JB Bjørås Magnar M Eide Lars L
PloS one 20140512 5
Mitochondrial DNA (mtDNA) mutations can result in mitochondrial dysfunction, but emerging experimental data question the fundamental role of mtDNA mutagenesis in age-associated mitochondrial impairment. The multicopy nature of mtDNA renders the impact of a given mtDNA mutation unpredictable. In this study, we compared mtDNA stability and mtRNA integrity during normal aging. Seven distinct sites in mouse brain mtDNA and corresponding mtRNA were analyzed. Accumulation of mtDNA mutations during agi ...[more]
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