Unknown

Dataset Information

0

Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.


ABSTRACT: This study examined the associations between pesticide exposure, genetic polymorphisms forquinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confidence interval): 1.68 (1.23-2.29)) in a dose-dependent manner. The association was slightly stronger for urothelial (1.79 (1.25-2.56)) than for squamous cell (1.55 (1.03-2.31)), and among participants with combined genotypes for low NQO1 and high SOD2 (2.14 (1.19-3.85)) activities as compared with those with high NQO1 and low SOD2 genotypes (1.53 (0.73-3.25)). In conclusion, among male agricultural workers in Egypt, pesticide exposure is associated with bladder cancer risk and possibly modulated by genetic polymorphism.

SUBMITTER: Amr S 

PROVIDER: S-EPMC4018465 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.

Amr Sania S   Dawson Rebecca R   Saleh Doa'a A DA   Magder Laurence S LS   St George Diane Marie DM   El-Daly Mai M   Squibb Katherine K   Mikhail Nabiel N NN   Abdel-Hamid Mohamed M   Khaled Hussein H   Loffredo Christopher A CA  

Archives of environmental & occupational health 20150101 1


This study examined the associations between pesticide exposure, genetic polymorphisms for<h4>Nad(p)h</h4>quinone oxidoreductase I (NQO1) and superoxide dismutase 2 (SOD2), and urinary bladder cancer risk among male agricultural workers in Egypt. Logistic regression was used to analyze data from a multicenter case-control study and estimate adjusted odds ratio (OR) and 95% confidence interval (CI). Exposure to pesticides was associated with increased bladder cancer risk (odds ratio (95% confiden  ...[more]

Similar Datasets

| S-EPMC3500531 | biostudies-literature
| S-EPMC7312224 | biostudies-literature
| S-EPMC3926695 | biostudies-literature
| S-EPMC3513664 | biostudies-literature
| S-EPMC1865553 | biostudies-literature
| S-EPMC8322659 | biostudies-literature
| S-EPMC6371456 | biostudies-literature
| S-EPMC9258647 | biostudies-literature
| S-EPMC4051574 | biostudies-literature
| S-EPMC8484858 | biostudies-literature