Functional promoter -765 G?>?C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women.

ABSTRACT: BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influence its expression. Herein, the present study was aimed to investigate the associations between two mostly studied functional polymorphisms (-765 G?>?C and 8473 C?>?T) in COX-2 and breast cancer risk in Chinese Han women. METHODS:In the hospital-based case-control study, 465 breast cancer patients and 799 cancer-free controls were genotyped for the COX-2 -765 G?>?C and 8473 C?>?T polymorphisms using TaqMan assay. We estimated odds ratios (ORs) and 95% confidence intervals (95% CIs) using the logistic regression. RESULTS:Compared with the wild genotype of -765 G?>?C, we found a statistically significant increased risk of breast cancer associated with the variant genotypes [GC/CC vs. GG: OR?=?1.56, 95% CI?=?1.11-2.21]. In the stratified analysis, the increased risk was more predominant among the subgroups of younger subjects (OR?=?1.61, 95% CI?=?1.00-2.61). Furthermore, the variant genotypes were associated with large tumor size (OR?=?3.01, 95% CI?=?1.47-6.12). No significant association was observed for the 8473 C?>?T polymorphism. CONCLUSIONS:Our results suggest that the functional -765 G?>?C polymorphism in the promoter of COX-2 may influence the susceptibility and progression of breast cancer in the Chinese Han population.

SUBMITTER: Gao J 

PROVIDER: S-EPMC4018614 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature