Beyond Warburg effect--dual metabolic nature of cancer cells.
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ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC4018627 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Beyond Warburg effect--dual metabolic nature of cancer cells.
Xie Jiansheng J Wu Hao H Dai Chunyan C Pan Qiangrong Q Ding Zonghui Z Hu Danqing D Ji Bingyan B Luo Yan Y Hu Xun X
Scientific reports 20140513
Warburg effect is a dominant phenotype of most cancer cells. Here we show that this phenotype depends on its environment. When cancer cells are under regular culture condition, they show Warburg effect; whereas under lactic acidosis, they show a nonglycolytic phenotype, characterized by a high ratio of oxygen consumption rate over glycolytic rate, negligible lactate production and efficient incorporation of glucose carbon(s) into cellular mass. These two metabolic modes are intimately interrelat ...[more]
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