Protection against oxidative DNA damage and stress in human prostate by glutathione S-transferase P1.
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ABSTRACT:
SUBMITTER: Kanwal R
PROVIDER: S-EPMC4018746 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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Protection against oxidative DNA damage and stress in human prostate by glutathione S-transferase P1.
Kanwal Rajnee R Pandey Mitali M Bhaskaran Natarajan N Maclennan Gregory T GT Fu Pingfu P Ponsky Lee E LE Gupta Sanjay S
Molecular carcinogenesis 20120725 1
The pi-class glutathione S-transferase (GSTP1) actively protect cells from carcinogens and electrophilic compounds. Loss of GSTP1 expression via promoter hypermethylation is the most common epigenetic alteration observed in human prostate cancer. Silencing of GSTP1 can increase generation of reactive oxygen species (ROS) and DNA damage in cells. In this study we investigated whether loss of GSTP1 contributes to increased DNA damage that may predispose men to a higher risk of prostate cancer. We ...[more]
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