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Human monocytes have increased IFN-?-mediated IL-15 production with age alongside altered IFN-? receptor signaling.

ABSTRACT: IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-?. Although aging can alter the immune system, little is known about whether and how aging affects IFN-?-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age ? 65) had increased cell surface IL-15 expression in response to IFN-? compared to those of healthy young adults (age ? 40). This finding stems in part from increased IFN-? receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-?-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults.

SUBMITTER: Lee N 

PROVIDER: S-EPMC4018768 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature

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Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling.

Lee Naeun N   Shin Min Sun MS   Kang Ki Soo KS   Yoo Seung-Ah SA   Mohanty Subhasis S   Montgomery Ruth R RR   Shaw Albert C AC   Kang Insoo I  

Clinical immunology (Orlando, Fla.) 20140319 1-2

IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age ≥ 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age ≤ 40). This finding stems in part  ...[more]

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